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Comment
. 2012 Oct 1;3(6):515-8.
doi: 10.4161/viru.21740. Epub 2012 Oct 1.

Uptake of Shigella-containing pseudopodia by neighboring epithelial cells at tricellular junctions via non-canonical clathrin-dependent trafficking pathway

Makoto Fukumatsu  1 , Michinaga Ogawa, Minsoo Kim, Hitomi Mimuro, Chihiro Sasakawa
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Comment

Uptake of Shigella-containing pseudopodia by neighboring epithelial cells at tricellular junctions via non-canonical clathrin-dependent trafficking pathway

Makoto Fukumatsu et al. Virulence. .
No abstract available

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Figure 1. Proposed model for Shigella cell-cell spreading. When Shigella moves from one epithelial cell to neighboring epithelial cells, Shigella-containing pseudopodia target tricellular tight junctions. PI 3-kinase is activated upon formation of a Shigella-containing pseudopodium. PI 3-kinase activity is required to recruit clathrin to the plasma membrane where the bacteria-containing pseudopodium was engulfed. Finally, an elongating pseudopodium is fully engulfed and undergoes clathrin-dependent endocytosis by a neighboring cell. Then, Shigella lyses the double plasma membranes and obtains the actin-based motility. Shigella can spread cell-to-cell repeat these process.
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