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. 2013 Jan;87(1):697-700.
doi: 10.1128/JVI.02180-12. Epub 2012 Oct 17.

High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover

M A Neller  1 , J M Burrows, M J Rist, J J Miles, S R Burrows
Affiliations

High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover

M A Neller et al. J Virol. 2013 Jan.

Abstract

High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little.

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References

    1. Arstila TP, Casrouge A, Baron V, Even J, Kanellopoulos J, Kourilsky P. 1999. A direct estimate of the human alphabeta T cell receptor diversity. Science 286:958–961 - PubMed
    1. Arstila TP, Casrouge A, Baron V, Even J, Kanellopoulos J, Kourilsky P. 2000. Diversity of human alpha beta T cell receptors. Science 288:1135. - PubMed
    1. Warren RL, Freeman JD, Zeng T, Choe G, Munro S, Moore R, Webb JR, Holt RA. 2011. Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes. Genome Res. 21:790–797 - PMC - PubMed
    1. Miles JJ, Douek DC, Price DA. 2011. Bias in the alphabeta T-cell repertoire: implications for disease pathogenesis and vaccination. Immunol. Cell Biol. 89:375–387 - PubMed
    1. Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682–687 - PubMed

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