Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct 18:12:66.
doi: 10.1186/1471-2466-12-66.

Predictive value of daily living score in acute respiratory failure of COPD patients requiring invasive mechanical ventilation pilot study

Ketty Langlet  1 , Thierry Van Der Linden, Claire Launois, Caroline Fourdin, Philippe Cabaret, Nadia Kerkeni, Coralie Barbe, François Lebargy, Gaetan Deslée
Affiliations

Predictive value of daily living score in acute respiratory failure of COPD patients requiring invasive mechanical ventilation pilot study

Ketty Langlet et al. BMC Pulm Med. .

Abstract

Background: Mechanical ventilation (MV) is imperative in many forms of acute respiratory failure (ARF) in COPD patients. Previous studies have shown the difficulty to identify parameters predicting the outcome of COPD patients treated by invasive MV. Our hypothesis was that a non specialized score as the activities daily living (ADL) score may help to predict the outcome of these patients.

Methods: We studied the outcome of 25 COPD patients admitted to the intensive care unit for ARF requiring invasive MV. The patients were divided into those weaning success (group A n = 17, 68%) or failure (group B n = 8, 32%). We investigated the correlation between the ADL score and the outcome and mortality.

Results: The ADL score was higher in group A (5.1 ±1.1 vs 3.7 ± 0.7 in group B, p < 0.01). Weaning was achieved in 76.5% of the cases with an ADL score ≥ 4 and in 23.5% of the cases with an ADL score < 4 (p < 0.05). Pulmonary function test, arterial blood gases collected during period of clinical stability and at admission and nutritional status were similar in both groups. The mortality, at six months, was 36%. The ADL score was a significant predictor of 6-month mortality (80 with an ADL score <4, 20 with an ADL score ≥4, p < 0.01).

Conclusion: Our pilot study demonstrates that the ADL score is predictive of weaning success and mortality at 6 months, suggesting that the assessment of daily activities should be an important component of ARF management in COPD patients.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Studied and excluded patients.
Figure 2
Figure 2
A. Weaning and ADL score. B. Percentage of weaning success according to ADL score.
Figure 3
Figure 3
Kaplan-Meier Survival curve of the weaned and not weaned groups.
See this image and copyright information in PMC

References

    1. Ram FS, Picot J, Lightowler J, Wedzicha JA. Non invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2004. CD 004104. - PubMed
    1. Nava S, Rubini F, Zanotti E, Ambrosino N, Bruschi C, Vitacca M, Fracchia C, Rampulla C. Survival and prediction of successful ventilator weaning in COPD patients requiring mechanical ventilation for more than 21 days. Eur Respir J. 1994;7(9):1645–1652. doi: 10.1183/09031936.94.07091645. - DOI - PubMed
    1. Menzies R, Gibbons W, Goldberg P. Determinants of weaning and survival among patients with COPD who require mechanical ventilation for acute respiratory failure. Chest. 1989;95(2):398–405. doi: 10.1378/chest.95.2.398. - DOI - PubMed
    1. Kaelin RM, Assimacopoulos A, Chevrolet JC. Failure to predict six-month survival of patients with COPD requiring mechanical ventilation by analysis of simple indices. A prospective study. Chest. 1987;92(6):971–978. doi: 10.1378/chest.92.6.971. - DOI - PubMed
    1. Carlucci A, Delmastro M, Rubini F, Fracchia C, Nava S. Changes in the practice of non–invasive ventilation in treating COPD patients over 8 years. Intensive Care Med. 2003;29(3):419–425. - PubMed

MeSH terms