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Comment
. 2012 Oct 16;22(4):419-20.
doi: 10.1016/j.ccr.2012.09.024.

Cell cycle-based therapies move forward

Marcos Malumbres  1
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Free article
Comment

Cell cycle-based therapies move forward

Marcos Malumbres. Cancer Cell. .
Free article

Abstract

Targeted therapies directed against cell cycle regulators have been difficult to translate into the clinic. In this issue of Cancer Cell, Choi et al. and Sawai et al. rekindle the therapeutic value of inhibiting specific cyclin-dependent kinase complexes by demonstrating their requirements in the maintenance of breast tumors and leukemias.

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  • The requirement for cyclin D function in tumor maintenance.
    Choi YJ, Li X, Hydbring P, Sanda T, Stefano J, Christie AL, Signoretti S, Look AT, Kung AL, von Boehmer H, Sicinski P. Choi YJ, et al. Cancer Cell. 2012 Oct 16;22(4):438-51. doi: 10.1016/j.ccr.2012.09.015. Cancer Cell. 2012. PMID: 23079655 Free PMC article.

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