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Comment
. 2012 Oct 16;22(4):421-2.
doi: 10.1016/j.ccr.2012.09.018.

The not-so-skinny on muscle cancer

Ken Kikuchi  1 , Charles Keller
Affiliations
Comment

The not-so-skinny on muscle cancer

Ken Kikuchi et al. Cancer Cell. .

Abstract

The childhood cancer embryonal rhabdomyosarcoma can arise in tissue without skeletal muscle elements. In this issue of Cancer Cell, Hatley and colleagues report that non-skeletal muscle progenitors can be a cell of origin for Sonic Hedgehog-driven embryonal rhabdomyosarcoma in an adipocyte-restricted conditional mouse model.

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Figures

Figure 1
Figure 1. Model of skeletal myogenesis and possible cellular origins of eRMS
Postnatal muscle maintenance and regeneration are regulated by Pax3, Pax7 and muscle regulatory factors (MyoD, Myf5, Myogenin and Myf6). Studies described in the text suggest that the cells of origin for eRMS include differentiating myoblasts and adipocytes.
See this image and copyright information in PMC

Comment on

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