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Comment
. 2012 Oct 16;22(4):423-4.
doi: 10.1016/j.ccr.2012.09.023.

A mitochondrial power play in lymphoma

Ralph J Deberardinis  1
Affiliations
Comment

A mitochondrial power play in lymphoma

Ralph J Deberardinis. Cancer Cell. .

Abstract

Deregulated energetics is a hallmark of malignancy, but metabolic heterogeneity among individual tumors is unknown. A study by Caro et al. in this issue of Cancer Cell demonstrates that a subset of lymphomas is defined by reliance on mitochondrial energy generation and is selectively killed when this pathway is impaired.

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Figures

Figure 1
Figure 1
Variable reliance on oxidative phosphorylation in DLBCL. Cells produce ATP from glycolysis (blue pathway) and oxidative phosphorylation (OxPhos, green). Cancer cell lines vary according to what fraction of their total ATP comes from each pathway, as shown on the spectrum at the bottom. A subset of DLBCL tumors was defined by high expression of genes related to OxPhos. These cells produced most of their ATP from OxPhos and required this pathway for survival and growth. Non-OxPhos cells, which did not share this gene expression signature, produced a higher fraction of their ATP from glycolysis, and were resistant to OxPhos inhibition. Abbreviation: TCA, tricarboxylic.
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References

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