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. 2013 Jan;41(Database issue):D1222-7.
doi: 10.1093/nar/gks949. Epub 2012 Oct 17.

The IMGT/HLA database

James Robinson  1 , Jason A Halliwell, Hamish McWilliam, Rodrigo Lopez, Peter Parham, Steven G E Marsh
Affiliations

The IMGT/HLA database

James Robinson et al. Nucleic Acids Res. 2013 Jan.

Abstract

It is 14 years since the IMGT/HLA database was first released, providing the HLA community with a searchable repository of highly curated HLA sequences. The HLA complex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of diverse function. Of these, 21 genes encode proteins of the immune system that are highly polymorphic. The naming of these HLA genes and alleles and their quality control is the responsibility of the World Health Organization Nomenclature Committee for Factors of the HLA System. Through the work of the HLA Informatics Group and in collaboration with the European Bioinformatics Institute, we are able to provide public access to these data through the website http://www.ebi.ac.uk/imgt/hla/. Regular updates to the website ensure that new and confirmatory sequences are dispersed to the HLA community and the wider research and clinical communities. This article describes the latest updates and additional tools added to the IMGT/HLA project.

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Figures

Figure 1.
Figure 1.
The number of HLA alleles named each year and included in the IMGT/HLA Database. The recent surge in the number of submissions received by the database is clearly shown.
Figure 2.
Figure 2.
The IMGT/HLA homepage, which acts as a portal to the different tools provided on the website.
Figure 3.
Figure 3.
The IMGT/HLA export combines a number of existing file formats and data source into a single format. The data are available from the IMGT/HLA database. The tool set is available from the Bioinformatics Group, of the National Marrow Donor Program. Together these allow the user to import the HLA data directly into their local database structure.
See this image and copyright information in PMC

References

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