Review
doi: 10.1111/jvp.12010.
Epub 2012 Oct 22.
Pharmacokinetics of macrolides in foals
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- PMID: 23082900
- DOI: 10.1111/jvp.12010
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Review
Pharmacokinetics of macrolides in foals
J Vet Pharmacol Ther.
2013 Feb.
Abstract
Macrolides are used for treatment of pneumonia and extrapulmonary conditions caused by Rhodococcus equi. In foals, macrolides have an extraordinary capacity to accumulate in different lung tissue compartments. These drugs show unique pharmacokinetic features such as rapid and extensive distribution and long persistence in pulmonary epithelial lining fluid (PELF) and bronchoalveolar lavage (BAL) cells from foals. This article reviews the pharmacokinetic characteristics of erythromycin, azithromycin, clarithromycin, tulathromycin, telithromycin, gamithromycin, and tilmicosin in foals, with emphasis on PELF and BAL cell concentrations.
© 2012 Blackwell Publishing Ltd.
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