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. 2012 Dec;26(4):931-48.
doi: 10.1016/j.idc.2012.08.004. Epub 2012 Sep 10.

Treatment of hepatitis C in patients infected with human immunodeficiency virus in the direct-acting antiviral era

Vincent Soriano  1 , Pablo Labarga, Eugenia Vispo, José Vicente Fernández-Montero, Pablo Barreiro
Affiliations

Treatment of hepatitis C in patients infected with human immunodeficiency virus in the direct-acting antiviral era

Vincent Soriano et al. Infect Dis Clin North Am. 2012 Dec.

Abstract

Chronic hepatitis C is a leading cause of clinical complications and mortality in individuals infected with human immunodeficiency virus (HIV). Approval for the first direct-acting antiviral (DAA) against the hepatitis C virus (HCV) has been eagerly awaited for treating patients coinfected with HIV/HCV. The use of first-generation HCV protease inhibitors is challenged by complicated dosing schedules, frequent serious toxicities, unwanted drug interactions, drug resistance, and high cost. First-generation DAAs will eventually be replaced by more potent, well-tolerated, and convenient agents. HIV/HCV co-infection will become restricted to individuals without proper access to health care.

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