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Review
. 2012 Nov;98(5):1061-5.
doi: 10.1016/j.fertnstert.2012.09.018.

Early pregnancy failure: beware of the pitfalls of modern management

Kurt T Barnhart  1
Affiliations
Review

Early pregnancy failure: beware of the pitfalls of modern management

Kurt T Barnhart. Fertil Steril. 2012 Nov.

Abstract

The evolution of the diagnosis and management of women with an early pregnancy loss has been a success story. The mortality from ectopic pregnancy has objectively been decreased in the past few decades. However, modern management has resulted in a new set of issues. Over-interpretation of a single ultrasound, misunderstanding of the utility of serial hCG values, and inappropriate use of methotrexate can result in iatrogenic complications. Modern management has successfully improved the diagnosis of ectopic pregnancy before rupture; it should now also focus on ensuring that an intrauterine pregnancy is not interrupted as a result of diagnosis and treatment. This article reviews some of the pitfalls of the modern management of early pregnancy failure and introduces a series of articles on the subject.

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References

    1. Hoover KW, Tao G, Kent CK. Trends in the diagnosis and treatment of ectopic pregnancy in the United States. Obstet Gynecol. 2010;115:495–502. - PubMed
    1. Creanga AA, Shapiro-Mendoza CK, Bish CL, Zane S, Berg CJ, Callaghan WM. Trends in ectopic pregnancy mortality in the united states, 1980–2007. Obstet Gynecol. 2011;117:837–43. - PubMed
    1. van Mello N, Mol F, Ankum, Mol B, van der Venn Hajenius. Ectopic pregnancy: how the diagnostic and therapeutic management has changed. Fertil Steril. 2012 - PubMed
    1. Morse CB, Sammel MD, Shaunik A, Allen-Taylor L, Oberfoell NL, Takacs P, Chung K, Barnhart KT. Performance of human chorionic gonadotropin curves in women at risk for ectopic pregnancy: Exceptions to the rules. Fertil Steril. 2012;97:101–106. - PMC - PubMed
    1. Barnhart KT. Ectopic pregnancy. New Engl J Med. 2009;361:379–87. - PubMed

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