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Comment
. 2012 Oct 19;37(4):591-3.
doi: 10.1016/j.immuni.2012.10.004.

New tricks from an old master

Kenneth M Murphy  1
Affiliations
Comment

New tricks from an old master

Kenneth M Murphy. Immunity. .

Abstract

In this issue of Immunity, Zhu et al. (2012) report a mouse reporter strain for the transcription factor T-bet. This reagent provides for the resolution of some longstanding issues in T helper cell development.

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Figures

Figure 1
Figure 1
Reporting T-bet's expression. The production of a GFP reporter mouse for the “master” transcription factor T-bet allows for clearer separation in analysis of T-bet expression and its actions on IFN-γ production. Results based on this reporter imply that stabilization of Th1 and Th2 cells may operate by somewhat different circuitry, with T-bet not necessarily feeding back on its own expression in the same manner as exhibited by GATA3. In addition, the findings confirm a mechanism reported earlier in which T-bet may directly repress the Th2 cell differentiation program – perhaps through direct interactions with GATA3 – and that T-bet and STAT4 cooperatively regulate Th1 cell-related genes, rather than one acting before the other in a strictly linear model.
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Comment on

References

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