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Review
. 2012 Nov;39(4):435-52.
doi: 10.1016/j.ucl.2012.07.002. Epub 2012 Aug 27.

Biology of castration-recurrent prostate cancer

Faris Azzouni  1 , James Mohler
Affiliations
Review

Biology of castration-recurrent prostate cancer

Faris Azzouni et al. Urol Clin North Am. 2012 Nov.

Abstract

Although androgen-deprivation therapy is the standard therapy for advanced and metastatic prostate cancer, this treatment is only palliative. Prostate cancer recurs then grows despite low circulating testicular androgens, using several mechanisms that remain dependent on androgen-receptor signaling in most cases. This article reviews the diversity of mechanisms used for growth by castration-recurrent prostate cancer.

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