Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Nov;92(5):551-2.
doi: 10.1038/clpt.2012.165.

A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates

L Z Benet  1
Affiliations
Comment

A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates

L Z Benet. Clin Pharmacol Ther. 2012 Nov.

Abstract

Understanding the metabolic, transporter, and genetic influences on the disposition of drugs used in chemotherapy is critical to individualization of drug therapy. Recognition of the importance of transporter-enzyme interplay, in which genetic variants of drug uptake transporters can change drug metabolism when the enzymes are unchanged, is an important advance in predicting appropriate drug dosage regimens for the individual patient.

PubMed Disclaimer

Comment on

  • OATP1B1 polymorphism as a determinant of erythromycin disposition.
    Lancaster CS, Bruun GH, Peer CJ, Mikkelsen TS, Corydon TJ, Gibson AA, Hu S, Orwick SJ, Mathijssen RH, Figg WD, Baker SD, Sparreboom A. Lancaster CS, et al. Clin Pharmacol Ther. 2012 Nov;92(5):642-50. doi: 10.1038/clpt.2012.106. Epub 2012 Sep 19. Clin Pharmacol Ther. 2012. PMID: 22990751 Free PMC article. Clinical Trial.

MeSH terms

Substances

LinkOut - more resources