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. 2012 Nov;92(5):553-6.
doi: 10.1038/clpt.2012.126.

Highlights from the International Transporter Consortium second workshop

M J Zamek-Gliszczynski  1 , K A Hoffmaster, D J Tweedie, K M Giacomini, K M Hillgren
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Highlights from the International Transporter Consortium second workshop

M J Zamek-Gliszczynski et al. Clin Pharmacol Ther. 2012 Nov.

Abstract

The Second International Transporter Consortium (ITC) Workshop was held with the purpose of expanding on previous white-paper recommendations, discussing recent regulatory draft guidance documents on transporter-drug interactions, and highlighting transporter-related challenges in drug development. Specific goals were to discuss additional clinically relevant transporters (MATEs, MRP2, BSEP) and best-practice methodologies and to re-evaluate ITC decision trees based on actual case studies. The outcome of the workshop will be a series of white papers targeted for publication in 2013.

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