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Review
. 2012 Dec 14;287(51):42444-52.
doi: 10.1074/jbc.R112.402768. Epub 2012 Oct 18.

From sirtuin biology to human diseases: an update

Carlos Sebastián  1 , F Kyle Satterstrom, Marcia C Haigis, Raul Mostoslavsky
Affiliations
Review

From sirtuin biology to human diseases: an update

Carlos Sebastián et al. J Biol Chem. .

Abstract

Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of NAD(+)-dependent enzymes that have been connected to a steadily growing set of biological processes. In addition to regulating aging, sirtuins play key roles in the maintenance of organismal metabolic homeostasis. These enzymes also have primarily protective functions in the development of many age-related diseases, including cancer, neurodegeneration, and cardiovascular disease. In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas.

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Figures

FIGURE 1.
FIGURE 1.
Metabolic functions of mammalian sirtuins in different tissues. For specific molecular targets, see text. PGC1α, PPARγ coactivator 1α; PEPCK, phosphoenolpyruvate carboxykinase; LCAD, long-chain acyl-CoA dehydrogenase; OTC, ornithine transcarbamoylase.
FIGURE 2.
FIGURE 2.
Mammalian sirtuins in carcinogenesis. The roles of sirtuins in initiation and tumor progression are summarized. For molecular targets, see text. ERα, estrogen receptor-α.
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