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Review
. 2012 Dec;20(6):360-8.
doi: 10.1258/vasc.2011.201205. Epub 2012 Oct 19.

Cell-based interventions for therapeutic angiogenesis: review of potential cell sources

Robert A Brenes  1 , Mackenzie Bear, Caroline Jadlowiec, Matthew Goodwin, Peter Hashim, Clinton D Protack, Kenneth R Ziegler, Xin Li, Lynn S Model, Wei Lv, Michael J Collins, Alan Dardik
Affiliations
Review

Cell-based interventions for therapeutic angiogenesis: review of potential cell sources

Robert A Brenes et al. Vascular. 2012 Dec.

Abstract

Alternative therapies are currently being developed to treat patients with chronic limb ischemia who are unable to be revascularized in order to avoid amputation. Cell-based therapy using mononuclear cells is gaining attention as many clinical trials are currently underway. We review cell differentiation along with the different potential cell sources for use in therapeutic angiogenesis.

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Figures

Figure 1
Figure 1
Hematopoietic stem cell (HSC) differentiation Legend: CFU=colony forming unit
Figure 2
Figure 2
Endothelial progenitor cell (EPC) transit from the bone marrow to the periphery
See this image and copyright information in PMC

References

    1. Norgren L, Hiatt WR, Dormandy JA, et al. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II) J Vasc Surg. 2007;45(Suppl S):S5–67. - PubMed
    1. Rivard A, Fabre JE, Silver M, et al. Age-dependent impairment of angiogenesis. Circulation. 1999;99(1):111–20. - PubMed
    1. Rajagopalan S, Mohler ER, 3rd, Lederman RJ, et al. Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. Circulation. 2003;108(16):1933–8. - PubMed
    1. Tateishi-Yuyama E, Matsubara H, Murohara T, et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet. 2002;360(9331):427–35. - PubMed
    1. Miyamoto K, Nishigami K, Nagaya N, et al. Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans. Circulation. 2006;114(24):2679–84. - PubMed

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