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. 2012 Oct 18:3:140.
doi: 10.3389/fneur.2012.00140. eCollection 2012.

The value of glioma extent of resection in the modern neurosurgical era

Douglas A Hardesty  1 , Nader Sanai
Affiliations

The value of glioma extent of resection in the modern neurosurgical era

Douglas A Hardesty et al. Front Neurol. .

Abstract

Objective: There remains no general consensus in the neurosurgical oncology literature regarding the role of extent of glioma resection in improving patient outcome. Although the value of resection in establishing a diagnosis and alleviating mass effect is clear, there is less certainty in ascertaining the influence of extent of resection (EOR). Here, we review the recent literature to synthesize a comprehensive review of the value of extent of resection for gliomas in the modern neurosurgical era.

Methods: We reviewed every major peer-reviewed clinical publication since 1990 on the role of EOR in glioma outcome.

Results: Thirty-two high-grade glioma articles and 11 low-grade glioma articles were examined in terms of quality of evidence, expected EOR, and survival benefit.

Conclusion: Despite limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade newly diagnosed gliomas.

Keywords: extent of resection; glioma; high-grade glioma; low-grade glioma; malignant transformation.

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References

    1. Barker F. G., II, Prados M. D., Chang S. M., Gutin P. H., Lamborn K. R., Larson D. A., et al. (1996). Radiation response and survival time in patients with glioblastoma multiforme. J. Neurosurg. 84, 442–44810.3171/jns.1996.84.3.0442 - DOI - PubMed
    1. Brown P. D., Maurer M. J., Rummans T. A., Pollock B. E., Ballman K. V., Sloan J. A., et al. (2005). A prospective study of quality of life in adults with newly diagnosed high-grade gliomas: the impact of the extent of resection on quality of life and survival. Neurosurgery 57, 495–504; discussion 495–504.10.1227/01.NEU.0000170562.25335.C7 - DOI - PubMed
    1. Buckner J. C., Schomberg P. J., McGinnis W. L., Cascino T. L., Scheithauer B. W., O’Fallon J. R., et al. (2001). A phase III study of radiation therapy plus carmustine with or without recombinant interferon-alpha in the treatment of patients with newly diagnosed high-grade glioma. Cancer 92, 420–43310.1002/1097-0142(20010715)92:2<420::AID-CNCR1338>3.0.CO;2-3 - DOI - PubMed
    1. Claus E. B., Horlacher A., Hsu L., Schwartz R. B., Dello-Iacono D., Talos F., et al. (2005). Survival rates in patients with low-grade glioma after intraoperative magnetic resonance image guidance. Cancer 103, 1227–123310.1002/cncr.20867 - DOI - PubMed
    1. Curran W. J., Jr., Scott C. B., Horton J., Nelson J. S., Weinstein A. S., Nelson D. F., et al. (1992). Does extent of surgery influence outcome for astrocytoma with atypical or anaplastic foci (AAF)? A report from three Radiation Therapy Oncology Group (RTOG) trials. J. Neurooncol. 12, 219–22710.1007/BF00172709 - DOI - PubMed