Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Sep;16(5):754-8.
doi: 10.4103/2230-8210.100669.

Effect of maternal anthropometry and metabolic parameters on fetal growth

Subarna Mitra  1 , Sujata Misra, Prasanta K Nayak, Jaya Prakash Sahoo
Affiliations

Effect of maternal anthropometry and metabolic parameters on fetal growth

Subarna Mitra et al. Indian J Endocrinol Metab. 2012 Sep.

Abstract

Objective: The aim of this study was to determine the effect of maternal anthropometry and metabolic parameters on neonatal anthropometry.

Materials and methods: This observational cross-sectional study was conducted from January 2008 to June 2009 at a single tertiary care center. Maternal anthropometry and metabolic parameters like fasting serum insulin, lipid profile, and random blood glucose were estimated in 50 pregnant women at term. Detailed anthropometry of the neonates was performed.

Results: Large for gestational age (LGA) babies had higher maternal body mass index (BMI), fasting serum insulin, and cord blood insulin levels, and lower maternal high density lipoprotein (HDL) compared to appropriate for gestational age (AGA) group (P < 0.001). Among the maternal parameters, BMI, gestational age, fasting serum insulin, and random blood sugar (RBS) had significant positive correlation, while HDL had negative correlation with birth weight (P < 0.05). However, only maternal BMI was the significant predictor of neonatal birth weight on multiple regression analysis (ß = 0.340, P = 0.01).

Conclusion: The BMI of glucose-tolerant mother is more important than metabolic parameters in determining the birth weight of term babies.

Keywords: Appropriate for gestational age; anthropometry; body mass index; large for gestational age.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Correlation between maternal serum insulin and cord blood insulin
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Holmes RP, Holly JMP, Soothill PW. A prospective study of maternal serum insulin-like growth factor-I in pregnancies with appropriately grown or growth restricted fetuses. Br J Obstet Gynaecol. 1998;105:1273–8. - PubMed
    1. Catalano PM, Drago NM, Amini SB. Maternal carbohydrate metabolism and its relationship to fetal growth and body composition. Am J Obstet Gynecol. 1995;172:1464–70. - PubMed
    1. Verhaeghe J, van Bree R, van Herck E, Laureys J, Bouillon R, Van Assche FA. C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight. Am J Obstet Gynecol. 1993;169:89–97. - PubMed
    1. Merchant SS, Momin IA, Sewani AA, Zuberi NF. Effect of pre-pregnancy body mass index and gestational weight gain on birth weight. J Pak Med Assoc. 1999;49:23–5. - PubMed
    1. Dennedy MC, Avalos G, O’Reilly MW, O’Sullivan EP, Gaffney G, Dunne F. ATLANTIC-DIP: Raised Maternal Body Mass Index (BMI) Adversely Affects Maternal and Fetal Outcomes in Glucose-Tolerant Women according to International Association of Diabetes and Pregnancy Study Groups (IADPSG) Criteria. JCEM. 2012;97:E608–12. [Epub ahead of print] - PubMed