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Clinical Trial
. 1979 Nov-Dec;63(11-12):1707-11.

Treatment of grade III and IV astrocytomas with BCNU alone and in combination with VM-26 following surgery and radiation therapy

D L Sweet, F J Hendler, K Hanlon, J Hekmatpanah, M L Griem, E E Duda, B Mulligan, R L Wollman
  • PMID: 230893
Clinical Trial

Treatment of grade III and IV astrocytomas with BCNU alone and in combination with VM-26 following surgery and radiation therapy

D L Sweet et al. Cancer Treat Rep. 1979 Nov-Dec.

Abstract

Twenty-one patients with grade III or IV astrocytomas were assigned randomly to receive either BCNU alone or BCNU and VM-26 after surgery and radiation therapy. Patients surviving radiation therapy and receiving single-agent chemotherapy had a median survival of 14 months while those receiving combination chemotherapy had a median survival of 22 months (P greater than 0.05). None of the patients who failed BCNU-only therapy responded to VM-26. Performance status was not affected by either regimen. Computerized tomographic scanning of the brain was useful only in confirming tumor progression. Two patients died from BCNU-related interstitial pulmonary fibrosis.

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