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. 1990 Mar;87(5):2031-5.
doi: 10.1073/pnas.87.5.2031.

Habituation in the single cell: diminished secretion of norepinephrine with repetitive depolarization of PC12 cells

P N McFadden  1 , D E Koshland Jr
Affiliations

Habituation in the single cell: diminished secretion of norepinephrine with repetitive depolarization of PC12 cells

P N McFadden et al. Proc Natl Acad Sci U S A. 1990 Mar.

Abstract

Neuronally differentiated PC12 cells secrete decreasing amounts of [3H]norepinephrine when repetitively stimulated by depolarizing concentrations of potassium ion. The decreasing response shows attributes that have been classically ascribed to response habituation, a behavior commonly observed in nervous systems but found here in a homogeneous cell type. Alteration of the habituation pattern was caused by activators of the protein kinase C pathway and of voltage-gated calcium channels.

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