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Review
. 2012:8:569-80.
doi: 10.2147/VHRM.S25745. Epub 2012 Oct 10.

The potential benefit of stem cell therapy after stroke: an update

Soma Banerjee  1 , Deborah A Williamson, Nagy Habib, Jeremy Chataway
Affiliations
Review

The potential benefit of stem cell therapy after stroke: an update

Soma Banerjee et al. Vasc Health Risk Manag. 2012.

Abstract

Stroke is a leading cause of death and disability worldwide. Stem cell therapy is an emerging therapeutic modality with evidence of significant benefits in preclinical stroke models. A number of phase I and II clinical trials have now been completed, with several more currently under way. Translation to the bedside, however, remains a long way off, and there are many questions that remain unanswered. This review will summarize the current evidence and ongoing clinical trials worldwide, and explore the challenges to making this a realistic treatment option for the future.

Keywords: clinical trials; stem cells; stroke.

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Figures

Figure 1
Figure 1
Stem cell types used in stroke trials, and the proposed mechanisms of action. Abbreviations: UCB, umbilical cord blood; NSC, neuronal stem cell; BMMNC, bone marrow mononuclear cell; HSC, hematopoietic stem cell; MSC, mesenchymal stem cell.
Figure 2
Figure 2
Stroke Therapy Academic Industry Roundtable (STAIR) II recommendations. Adapted from Stroke Therapy Academic Industry Roundtable II (STAIR-II). Recommendations for clinical trial evaluation of acute stroke therapies. Stroke. 2001;32:1598–1606. Note: Important factors relevant to stem cell therapy underlined.
Figure 3
Figure 3
Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS) recommendations. Adapted from Stem Cell Therapies as an Emerging Paradigm in Stroke participants. Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke. 2009;40:510–515.
See this image and copyright information in PMC

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