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. 2012:2012:687424.
doi: 10.1155/2012/687424. Epub 2012 Oct 3.

P-cadherin expression in feline mammary tissues

Ana Catarina Figueira  1 , Ana Sofia Teodósio, Júlio Carvalheira, Manuela Lacerda, Augusto de Matos, Fátima Gärtner
Affiliations

P-cadherin expression in feline mammary tissues

Ana Catarina Figueira et al. Vet Med Int. 2012.

Abstract

The search for molecular markers in the feline mammary gland, namely, the adhesion molecules belonging to the cadherin family, is useful in the understanding of the development of mammary carcinomas in felines and humans. To study P-cadherin expression in the feline mammary gland, 61 samples of normal (n = 4), hyperplastic (n = 12), and neoplastic (n = 45) feline mammary tissues were examined. In both normal and hyperplastic mammary tissues as well as in benign tumours, P-cadherin immunolabelling was restricted to myoepithelial cells. In malignant tumours, however, there was an aberrant epithelial P-cadherin immunoexpression in 64.1% (n = 25) of cases, with a membranous and/or cytoplasmic pattern of distribution. A statistically significant relationship was seen between epithelial P-cadherin expression and malignant mammary lesions (P = 0.0001). In malignant mammary tumours, there was likewise a statistically significant relationship between aberrant P-cadherin immunoexpression and histological grade (P = 0.0132). Aberrant epithelial P-cadherin expression seems to be related to malignancy in the feline mammary gland. To confirm the results of this investigation, further studies with larger samples and follow-up studies are warranted.

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Figures

Figure 1
Figure 1
Normal mammary gland. Membranous and cytoplasmic P-cadherin immunoreactivity in myoepithelial cells (streptavidin-biotin-peroxidase method, 630x).
Figure 2
Figure 2
Fibroadenomatous change. Membranous and cytoplasmic P-cadherin immunoreactivity in myoepithelial cells (streptavidin-biotin-peroxidase method, 630x).
Figure 3
Figure 3
Solid carcinoma. Aberrant P-cadherin immunoreactivity in luminal epithelial cells (membranous and cytoplasmic) (streptavidin-biotin-peroxidase method, 100x).
Figure 4
Figure 4
Tubulopapillary carcinoma. Aberrant P-cadherin immunoreactivity in luminal epithelial cells (membranous and cytoplasmic) (streptavidin-biotin-peroxidase method, 100x).
Figure 5
Figure 5
Solid carcinoma. Membranous and granular cytoplasmic aberrant P-cadherin immunoreactivity in luminal epithelial cells (streptavidin-biotin-peroxidase method, 630x).
Figure 6
Figure 6
Tubulopapillary carcinoma. Strong aberrant P-cadherin immunoreactivity in the periphery of the tumour (streptavidin-biotin-peroxidase method, 100x).
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