Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec 7;48(94):11579-81.
doi: 10.1039/c2cc35973a.

Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

Weiguo Shi  1 , Lifeng Cai, Lu Lu, Chao Wang, Kun Wang, Liang Xu, Sha Zhang, Han Han, Xifeng Jiang, Baohua Zheng, Shibo Jiang, Keliang Liu
Affiliations

Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

Weiguo Shi et al. Chem Commun (Camb). .

Abstract

Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically interact with HIV-1 gp41, and show strong anti-HIV activity.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources