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Comment
. 2012 Nov;2(11):974-5.
doi: 10.1158/2159-8290.CD-12-0432. Epub 2012 Oct 23.

The potential of circulating tumor cells as a liquid biopsy to guide therapy in prostate cancer

Klaus Pantel  1 , Catherine Alix-Panabières
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Comment

The potential of circulating tumor cells as a liquid biopsy to guide therapy in prostate cancer

Klaus Pantel et al. Cancer Discov. 2012 Nov.

Abstract

Miyamoto and colleagues present data that prostate-specific antigen/prostate-specific membrane antigen (PSA/PSMA)-based measurements of androgen receptor (AR) signaling in circulating tumor cells (CTC) enable real-time quantitative monitoring of intratumoral AR signaling. This finding indicates that measuring AR signaling within CTCs may help to guide therapy in metastatic prostate cancer and highlights the use of CTCs as liquid biopsy.

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