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Comment
. 2012 Oct;35(5):363-4.
doi: 10.1017/S0140525X12001392.

Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence

Curtis K Deutsch  1 , William J McIlvane
Affiliations
Comment

Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence

Curtis K Deutsch et al. Behav Brain Sci. 2012 Oct.

Abstract

The target article by Charney on behavior genetics/genomics discusses how numerous molecular factors can inform heritability estimations and genetic association studies. These factors find application in the search for genes for behavioral phenotypes, including neuropsychiatric disorders. We elaborate upon how single causal factors can generate multiple phenotypes, and discuss how multiple causal factors may converge on common neurodevelopmental mechanisms.

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