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Editorial
. 2012 Dec 1;11(23):4285-6.
doi: 10.4161/cc.22465. Epub 2012 Oct 24.

Normalization of tumor vasculature by R-Ras

Junko Sawada, Masanobu Komatsu
Editorial

Normalization of tumor vasculature by R-Ras

Junko Sawada et al. Cell Cycle. .
No abstract available

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Figures

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Figure 1. Schematic summary of the consequences of R-Ras disruption and upregulation in tumor blood vessels. R-Ras is expressed at low levels in the endothelium and pericytes of tumor vessels. The disruption of R-Ras severely impairs structural and functional maturation of tumor vessels. These vessels exhibit the poorly pericyte-supported “vulnerable” immature phenotype. The vessel abnormalities result in extensive blood leakage, reduced blood perfusion and elevated hypoxia within tumors. On the other hand, upregulation of R-Ras signaling enhances pericyte association and stabilizes VE-cadherin-mediated endothelial adherens junctions, leading to improved vessel structure and endothelial barrier function with improved blood perfusion. Thus, R-Ras promotes normalization of pathologically regenerating blood vessels.
See this image and copyright information in PMC

Comment on

  • Sawada J, Urakami T, Li F, Urakami A, Zhu W, Fukuda M, Li DY, Ruoslahti E, Komatsu M. Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels. Cancer Cell. 2012;22:235–49. doi: 10.1016/j.ccr.2012.06.013. doi: 10.1016/j.ccr.2012.06.013

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