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Editorial
. 2012 Dec 1;11(23):4287-8.
doi: 10.4161/cc.22467. Epub 2012 Oct 24.

Transactivation by low and high levels of human p53 reveals new physical rules of engagement and novel super-transactivation sequences

Daniel Menendez, Michael A Resnick, Tali Haran
Editorial

Transactivation by low and high levels of human p53 reveals new physical rules of engagement and novel super-transactivation sequences

Daniel Menendez et al. Cell Cycle. .
No abstract available

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Figures

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Figure 1. Model of p53 bound to DNA at low (left) vs. high (right) p53 concentrations. p53 dimers are schematically represented by two connected balloons. The DNA RE is represented by a rectangular block when the DNA is rigid (containing the rigid CTAG motif) or by a wavy rectangular block when the DNA is flexible (containing the flexible CATG motif). The drawing is not to scale. The DNA double helix is narrower than the p53 spheres bound to it.
See this image and copyright information in PMC

Comment on

  • Jordan JJ, Menendez D, Sharav J, Beno I, Rosenthal K, Resnick MA, Haran TE. Low-level p53 expression changes transactivation rules and reveals superactivating sequences. Proc Natl Acad Sci USA. 2012;109:14387–92. doi: 10.1073/pnas.1205971109.

References

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    1. Jordan JJ, et al. Proc Natl Acad Sci USA. 2012;109:14387–92. doi: 10.1073/pnas.1205971109. - DOI - PMC - PubMed
    1. Beno I, et al. Nucleic Acids Res. 2011;39:1919–32. doi: 10.1093/nar/gkq1044. - DOI - PMC - PubMed
    1. Olson WK, et al. Proc Natl Acad Sci USA. 1998;95:11163–8. doi: 10.1073/pnas.95.19.11163. - DOI - PMC - PubMed

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