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Review
. 2012 Oct;8(10):1534-43.
doi: 10.4161/hv.22064. Epub 2012 Oct 1.

Recombinant allergens: the present and the future

Marek Jutel  1 , Katarzyna Solarewicz-Madejek, Sylwia Smolinska
Affiliations
Review

Recombinant allergens: the present and the future

Marek Jutel et al. Hum Vaccin Immunother. 2012 Oct.

Abstract

Allergen specific immunotherapy (SIT) is the only known causative treatment of allergic diseases. Recombinant allergen-based vaccination strategies arose from a strong need to both to improve safety and enhance efficacy of SIT. In addition, new vaccines can be effective in allergies including food allergy or atopic dermatitis, which poorly respond to the current treatment with allergen extracts. A number of successful clinical studies with both wild-type and hypoallergenic derivatives of recombinant allergens vaccines have been reported for the last decade. They showed high efficacy and safety profile as well as very strong modulation of T and B cell responses to specific allergens.

Keywords: allergen-specific immunotherapy; allergy; hypoallergens; recombinant allergens; vaccines.

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