[Continuous glucose monitoring in glimipiride plus metformin treated type 2 diabetic patients during the month of Ramadan]

Abstract

Background: Fasting during Ramadan may be a cause of poor glycaemic control in diabetic patients.

Aim: To assess glucose excursions during Ramadan by using a continuous glucose monitoring system (CGMS).

Methods: The interstitial glucose level was recorded over 72 hours during Ramadan and three months later, in five type 2 diabetic patients, aged 56 ± 5, treated with glimepiride and metformin.

Results: During Ramadan, four patients experienced at least one episode of low glucose level (<0.7 g/l) during the monitoring. The frequency of these episodes was 0.6 episode/d with an average duration of 36 mn / d. These episodes occurred in the morning in half of the cases and in the hour before breaking the fast in 37.5 % of the cases. Four patients experienced at least one episode of high glucose level (>1.8 g/l), with an average duration of 403 mn /d and with a frequency of two episodes /d. More than half episodes (53) occurred after the breaking of the fast. After Ramadan, CGM records showed at least one episode of low glucose in two patients with an average duration of 58 mn /d and a frequency of 1.3 episodes/d. Three patients experienced at least one episode of high glucose level with an average duration of 525 mn /d and a frequency of 1.46 episodes/day.

Conclusion: The blood glucose profile of our patients during Ramadan is characterized by important glycaemic excursions.