doi: 10.1016/0014-2999(79)90237-1.
Inhibition by digoxin and SC4453 of (Na+ + K+)-ATPase prepared from human heart, guinea-pig heart and guinea-pig brain
- PMID: 230981
- DOI: 10.1016/0014-2999(79)90237-1
Item in Clipboard
Inhibition by digoxin and SC4453 of (Na+ + K+)-ATPase prepared from human heart, guinea-pig heart and guinea-pig brain
Eur J Pharmacol.
.
Abstract
SC4453 is a digoxin analogue with a pyridazine instead of a lactone ring on C17 beta. SC4453 was compared with digoxin with respect to inhibition of (Na+ + K+)-ATPase prepared from human heart, guinea-pig heart and guinea-pig brain. SC4453 was slightly less potent than digoxin but showed a similar sensitivity to K+. As for cardenolides, species differences in sensitivity to SC4453 were accounted for by differences in the rate of dissociation from the receptors. These observations confirm that the human heart is one of the tissues most sensitive to cardiac glycosides.
Similar articles
-
Interaction of digoxin and SC4453 with the (Na+ + K+)-ATPase from guinea-pig heart and brain.Arch Int Pharmacodyn Ther. 1979 May;239(1):171-2. Arch Int Pharmacodyn Ther. 1979. PMID: 226021 No abstract available.
-
The cardioactive properties of SC4453, a digoxin analogue with a C17 beta-pyridazine ring.Eur J Pharmacol. 1979 Dec 20;60(4):337-44. doi: 10.1016/0014-2999(79)90238-3. Eur J Pharmacol. 1979. PMID: 527669
-
Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453.J Biol Chem. 1985 Jun 10;260(11):6843-50. J Biol Chem. 1985. PMID: 2987235
-
The biphasic action of cardiac glycosides on the Na+, K+-pump and its relevance in the treatment of heart failure.Eur Heart J. 1982 Dec;3 Suppl D:53-7. Eur Heart J. 1982. PMID: 6297911 Review. No abstract available.
-
Simplified digitalis-like compounds acting on Na(+), K(+)-ATPase.J Enzyme Inhib Med Chem. 2003 Aug;18(4):289-95. doi: 10.1080/1475636031000138750. J Enzyme Inhib Med Chem. 2003. PMID: 14567542 Review.
Cited by
-
Distribution of SC-4453, a new semi-synthetic derivative of digoxin, following an infusion preceded by an i.v. loading dose in the guinea-pig. Binding to plasma proteins.Eur J Drug Metab Pharmacokinet. 1988 Jan-Mar;13(1):19-22. doi: 10.1007/BF03189923. Eur J Drug Metab Pharmacokinet. 1988. PMID: 3396609
-
Possible mechanism of digoxin-induced convulsions.Psychopharmacology (Berl). 1983;79(2-3):287-9. doi: 10.1007/BF00427829. Psychopharmacology (Berl). 1983. PMID: 6405441
-
Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implications for sustained elevation of vascular resistance.Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1140-50. doi: 10.1152/ajpheart.00436.2009. Epub 2009 Jul 17. Am J Physiol Heart Circ Physiol. 2009. PMID: 19617413 Free PMC article.
-
Reduced cAMP levels and glycogen phosphorylase activation in isoproterenol perfused SHR myocardium.Basic Res Cardiol. 1983 Nov-Dec;78(6):695-705. doi: 10.1007/BF01907217. Basic Res Cardiol. 1983. PMID: 6318720
-
The lead structure in cardiac glycosides is 5 beta, 14 beta-androstane-3 beta 14-diol.Naunyn Schmiedebergs Arch Pharmacol. 1985 Jun;329(4):414-26. doi: 10.1007/BF00496377. Naunyn Schmiedebergs Arch Pharmacol. 1985. PMID: 4033807
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
