Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2013 Jun 5;166(1):246-8.
doi: 10.1016/j.ijcard.2012.09.027. Epub 2012 Oct 23.

Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium

Randomized Controlled Trial

Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium

Beamon Agarwal et al. Int J Cardiol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interests: The authors of this study have no conflicts of interest

Figures

Figure 1
Figure 1. Comparison of ICAM, VCAM, and IL-8 mRNA expression in human coronary endothelial artery cells incubated using plasma from subjects in this trial
Each pair of data points represents data from one subject at baseline and 30-days post treatment. The solid horizontal line and corresponding number is mean value for baseline and post-treatment data. Please note, the y-axis uses a logarithmic scale and represents mRNA expression in relative units (described previously[6]). There were significant (p<0.05) decreases in mRNA expression for ICAM, VCAM, and IL-8 for RESV, but not PLA. (ICAM = intracellular adhesion molecule; IL-8 = interleukin eight; mRNA = messenger ribonucleic acid; PLA = placebo; RESV = resveratrol; VCAM = vascular cell adhesion molecule)

References

    1. Smoliga JM, Baur JA, Hausenblas HA. Resveratrol and health--a comprehensive review of human clinical trials. Mol Nutr Food Res. 2011;55:1129–1141. - PubMed
    1. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5:493–506. - PubMed
    1. Schmidt C, Hulthe J, Fagerberg B. Baseline ICAM-1 and VCAM-1 are increased in initially healthy middle-aged men who develop cardiovascular disease during 6.6 years of follow-up. Angiology. 2009;60:108–114. - PubMed
    1. Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2010;122:e584–e636. - PubMed
    1. Luc G, Arveiler D, Evans A, Amouyel P, Ferrieres J, Bard JM, et al. Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and incident coronary heart disease: the PRIME Study. Atherosclerosis. 2003;170:169–176. - PubMed

Publication types