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Review
. 2012 Dec;41(4):735-45.
doi: 10.1016/j.ecl.2012.08.008.

Down syndrome and thyroid function

Evan Graber  1 , Elizabeth Chacko, Molly O Regelmann, Gertrude Costin, Robert Rapaport
Affiliations
Review

Down syndrome and thyroid function

Evan Graber et al. Endocrinol Metab Clin North Am. 2012 Dec.

Abstract

Thyroid dysfunction in children with Down syndrome (DS) can occur as early as birth. As children with DS age, their risk for thyroid autoimmunity manifested as autoimmune hypothyroidism or Graves disease increases. The optimal timing and method for thyroid screening in children with DS remains controversial. The American Academy of Pediatrics recommends annual screening in this population. Consensus is needed to establish working definitions of euthyroidism and mild hypothyroidism in all infants, but especially in those with DS.

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