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Review
. 2012 Dec;41(4):793-803.
doi: 10.1016/j.ecl.2012.08.002. Epub 2012 Sep 27.

Cushing syndrome in pediatrics

Constantine A Stratakis  1
Affiliations
Review

Cushing syndrome in pediatrics

Constantine A Stratakis. Endocrinol Metab Clin North Am. 2012 Dec.

Abstract

Cushing syndrome is characterized by truncal obesity, growth deceleration, skin changes, muscle weakness, and hypertension. Cushing syndrome in childhood usually results from the exogenous administration of glucocorticoids. This article presents the causes and discusses the treatment of endogenous Cushing syndrome. It also discusses the clinical and molecular genetics of inherited forms of this syndrome. Cushing syndrome needs to be diagnosed and treated properly when first recognized; improper treatment can turn this otherwise completely curable disorder into a chronic ailment. Barriers to optimal care of a pediatric patient with Cushing syndrome are discussed.

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Figures

Fig. 1
Fig. 1
Typical growth chart for a patient with Cushing syndrome.
Fig. 2
Fig. 2
Diagnostic algorithm in Cushing syndrome.
See this image and copyright information in PMC

References

    1. Magiakou MA, Mastorakos G, Oldfield EH, et al. Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy. N Engl J Med. 1994;331(10):629–36. - PubMed
    1. Lodish MB, Sinaii N, Patronas N, et al. Blood pressure in pediatric patients with Cushing syndrome. J Clin Endocrinol Metab. 2009;94(6):2002–8. - PMC - PubMed
    1. Tsigos C, Chrousos GP. Differential diagnosis and management of Cushing's syndrome. Annu Rev Med. 1996;47:443–61. - PubMed
    1. Orth DN. Cushing's syndrome. N Engl J Med. 1995;332(12):791–803. - PubMed
    1. Stratakis CA, Kirschner LS. Clinical and genetic analysis of primary bilateral adrenal diseases (micro- and macronodular disease) leading to Cushing syndrome. Horm Metab Res. 1998;30(6–7):456–63. - PubMed

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