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Review
. 2012 Dec;93(3):315-8.
doi: 10.1016/j.yexmp.2012.10.013. Epub 2012 Oct 23.

Host response in tumor diagnosis and prognosis: importance of immunologists and pathologists alliance

Olivera J Finn  1
Affiliations
Review

Host response in tumor diagnosis and prognosis: importance of immunologists and pathologists alliance

Olivera J Finn. Exp Mol Pathol. 2012 Dec.

Abstract

Pathologists and immunologists have collaborated over many years in their efforts to understand and properly diagnose cancer. The ability of pathologists to correctly diagnose this disease was facilitated by the development of immunohistology that utilized specificity of antibodies to distinguish between normal cells and cancer cells. Further boost was provided through the advent of monoclonal antibodies. The two disciplines are now together on the brink of a paradigm shift resulting from a better understanding of the importance for cancer diagnosis and prognosis to consider not only the characteristics of the cancer cells, but also the cancer microenvironment reflecting the host response to the disease. This new immunology and pathology alliance named "Immunoscore" will advance research in both disciplines as well as benefit patients.

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Figures

Figure 1
Figure 1
Immunohistology of primary colon tumors in a tissue microarray (TMA) showing examples of tumors with low (A and C) and high (B and D) CD8 T cell infiltration. Tumor is stained blue (cytokeratin) and CD8+ T cells brown. Images are courtesy of Dr. Jerome Galon.
Figure 1
Figure 1
Immunohistology of primary colon tumors in a tissue microarray (TMA) showing examples of tumors with low (A and C) and high (B and D) CD8 T cell infiltration. Tumor is stained blue (cytokeratin) and CD8+ T cells brown. Images are courtesy of Dr. Jerome Galon.
Figure 1
Figure 1
Immunohistology of primary colon tumors in a tissue microarray (TMA) showing examples of tumors with low (A and C) and high (B and D) CD8 T cell infiltration. Tumor is stained blue (cytokeratin) and CD8+ T cells brown. Images are courtesy of Dr. Jerome Galon.
Figure 1
Figure 1
Immunohistology of primary colon tumors in a tissue microarray (TMA) showing examples of tumors with low (A and C) and high (B and D) CD8 T cell infiltration. Tumor is stained blue (cytokeratin) and CD8+ T cells brown. Images are courtesy of Dr. Jerome Galon.
See this image and copyright information in PMC

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