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Case Reports
. 2013 Jan;27(1):101-2.
doi: 10.1038/eye.2012.221. Epub 2012 Oct 26.

Ranibizumab for the management of Sorsby fundus dystrophy

Case Reports

Ranibizumab for the management of Sorsby fundus dystrophy

K Balaskas et al. Eye (Lond). 2013 Jan.
No abstract available

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Figures

Figure 1
Figure 1
OCT frames OD, pretreatment, posttreatment, and 6 months after the last injection. (a) OCT frame OD, May 2009 (time of the first injection), showing active CNV with subretinal fluid. (b) OCT frame OD, February 2011 (time of last injection), showing subretinal fibrosis without subretinal fluid. There is a minimal residual intraretinal cyst. (c) OCT frame OD, August 2011 (6 months after last injection), confirming continuous disease quiescence.
Figure 2
Figure 2
Color Fundus Image OD, February 2011 (time of last injection), revealing fibrosed CNV adjacent to spared functional retina that includes the foveal region justifying preserved visual acuity.

References

    1. Sivaprasad S, Webster A, Egan C, Bird A, Tufail A. Clinical course and treatment outcomes of Sorsby fundus dystrophy. Am J Ophthalmol. 2008;146:228–234. - PubMed
    1. Weber BH, Vogt G, Pruett RC, Stohr H, Felbor U. Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy. Nat Genet. 1994;8:352–356. - PubMed
    1. Holz FG, Haimovici R, Wagner DG, Bird AC. Recurrent choroidal neovascularization after laser photocoagulation in Sorsby's fundus dystrophy. Retina. 1994;14:329–334. - PubMed
    1. Peiretti E, Klancnik JM, Spaide RF, Yannuzzi L. Choroidal neovascularization in Sorsby fundus dystrophy treated with photodynamic therapy and intravitreal triamcinolone acetonide. Retina. 2005;25:377–379. - PubMed
    1. Prager F, Michels S, Geitzenauer W, Schmidt-Erfurth U. Choroidal neovascularization secondary to Sorsby fundus dystrophy treated with systemic bevacizumab (Avastin) Acta Ophthalmol Scand. 2007;85 (8:904–906. - PubMed

Supplementary concepts