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Comment
. 2012 Nov 13;109(46):18635-6.
doi: 10.1073/pnas.1215857109. Epub 2012 Oct 25.

The neuraminidase of bat influenza viruses is not a neuraminidase

Adolfo García-Sastre  1
Affiliations
Comment

The neuraminidase of bat influenza viruses is not a neuraminidase

Adolfo García-Sastre. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
H1 to H16 HA subtypes bind to sialic acid-containing receptors and mediate influenza A virus entry. N1 to N9 NA subtypes cleave sialic acids and destroy the receptor, mediating virus spread. The structure of the N10 subtype from the recently discovered bat influenza viruses (2, 3) shows profound changes in the active site of this NA-like molecule that prevent sialidase activity. It remains to be determined (i) whether the H17 HA from bat influenza viruses binds sialic acids, (ii) what the receptor of bat influenza viruses is, and (iii) whether the N10 NA-like protein from bat influenza virus has receptor-destroying activity.
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References

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