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Comment
. 2012 Nov 13;109(46):18635-6.
doi: 10.1073/pnas.1215857109. Epub 2012 Oct 25.

The neuraminidase of bat influenza viruses is not a neuraminidase

Adolfo García-Sastre  1
Affiliations
Comment

The neuraminidase of bat influenza viruses is not a neuraminidase

Adolfo García-Sastre. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
H1 to H16 HA subtypes bind to sialic acid-containing receptors and mediate influenza A virus entry. N1 to N9 NA subtypes cleave sialic acids and destroy the receptor, mediating virus spread. The structure of the N10 subtype from the recently discovered bat influenza viruses (2, 3) shows profound changes in the active site of this NA-like molecule that prevent sialidase activity. It remains to be determined (i) whether the H17 HA from bat influenza viruses binds sialic acids, (ii) what the receptor of bat influenza viruses is, and (iii) whether the N10 NA-like protein from bat influenza virus has receptor-destroying activity.
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References

    1. Tong S, et al. A distinct lineage of influenza A virus from bats. Proc Natl Acad Sci USA. 2012;109(11):4269–4274. - PMC - PubMed
    1. Li Q, et al. Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus. Proc Natl Acad Sci USA. 2012;109:18897–18902. - PMC - PubMed
    1. Zhu X, et al. Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site. Proc Natl Acad Sci USA. 2012;109:18903–18908. - PMC - PubMed
    1. Colman PM, Varghese JN, Laver WG. Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature. 1983;303(5912):41–44. - PubMed
    1. Russell RJ, et al. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature. 2006;443(7107):45–49. - PubMed

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