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. 1997 Dec;12(1):49-54.
doi: 10.1007/BF02867955.

Characterisation of the canine cardiac sarcolemma in experimental myocardial ischemia

T J Netticadan  1 , T F Ashavaid, K G Nair
Affiliations

Characterisation of the canine cardiac sarcolemma in experimental myocardial ischemia

T J Netticadan et al. Indian J Clin Biochem. 1997 Dec.

Abstract

The cardiac sarcolemma was characterized in 13 normal and 11 ischemic dog hearts by enzyme analysis and compositional assays. Significant decreases in the activities of the sodium-potassium and calcium pumps and structural compositional disturbances were observed in ischemia. High concentrations of oleic acid, a fatty acid and palmitoyl carnitine, a fatty acid intermediate caused inhibition of the enzyme pump activities of the normal sarcolemma. Thus, ischemia results in the functional impairment of the sarcolemma. Accumulation of fatty acid and fatty acid intermediates, occurring in myocardial ischemia, could be an underlying mechanism.

Keywords: Myocardial ischaemia; canine cardiac sarcolemma.

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References

    1. Fleckenstein A., Janke J., Doring H.J., Pachinger O. Ca overload as the determinant factor in the production of catecholamine-induced myocardial lesions. Rec. Adv. Stud. Card. Met. 1973;2:455–466. - PubMed
    1. Dhalla N.S., Panagia V., Singal P.K., Makino N., Dixon I.M.C., Eyolfson D.A. Alterations in heart membrane calcium transport during the development of ischemia-reperfusion injury. J. Mol. Cell. Cardiol. 1988;20(Suppl II):3–13. doi: 10.1016/0022-2828(88)90327-6. - DOI - PubMed
    1. Daly M.J., Elz J.S., Nayler W.G. Sarcolemma enzymes and Na+—Ca2+ exchange in hypoxic, ischemic and reperfused rat hearts. Am. J. Physiol. 1984;247:4237–4243. - PubMed
    1. Katz A.M., Messineo F.C. Lipid-membrane interations and pathogenesis of ischemic damage in the myocardium. Circ. Res. 1981;48:1–16. - PubMed
    1. Chien K.R., Reeves J.P., Buja L.M., Bonte F., Parkey R.W., Willerson J.T. Phospholipid alterations in canine ischemic myocardium. Temporal and topographical correlations with Tc-99m-ppi accumulation and an in vitro sarcolemmal Ca2+ permeability defect. Circ. Res. 1981;48:711–718. - PubMed

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