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. 2007 Dec;23(3-4):99-103.
doi: 10.1007/s12288-008-0006-y. Epub 2008 Mar 19.

A study-screening of blood donors for blood transmissible diseases

S V Shinde  1 , G V Puranik
Affiliations

A study-screening of blood donors for blood transmissible diseases

S V Shinde et al. Indian J Hematol Blood Transfus. 2007 Dec.

Abstract

Aims: Blood donors are of voluntary and replacement type. All donors, especially voluntary, are considered as slow risk for seropositive status for Hepatitis B and C, HIV and syphilis. The present study endeavors to screen blood donors-a slow risk group and evaluate the resultant data.

Methodology: We screened 23,068 donors serologically over 2 years for the above blood transmissible diseases. Serum alanine aminotranferase (ALT) and bilirubin were evaluated as surrogate markers in hepatitis B and C positive donors.

Results: Seroprevalence rates were found to be HIV (1.96 %), syphilis (2.15 %), hepatitis B (1.98 %) and hepatitis C (0.9 %). Majority donors were voluntary (70.37 %) and male (96.2 %). However seroprevalence rates showed no significant difference: voluntary (7.02 %), replacement (6.67 %) male (6.85 %) and female (6.95 %). HCV and HIV showed highest (29.6 %) while HBV and HCV (2.5 %) showed lowest concomitance. Serum ALT and bilirubin were not effective surrogate markers. No demographic or behavioral variable was found as a significant risk factor.

Conclusion: Thus, all donors need adequate privacy, information, counseling and motivation in order to reduce the seropositive rates in donors. Advent of sensitive tests renders surrogate markers redundant.

Keywords: Concomitance; Seroprevalence; Surrogate marker.

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