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Comment
. 2012 Oct 26;151(3):473-5.
doi: 10.1016/j.cell.2012.10.016.

A tollgate for typhoid

Ferric C Fang  1 , Andreas J Bäumler
Affiliations
Comment

A tollgate for typhoid

Ferric C Fang et al. Cell. .

Abstract

Humans are uniquely susceptible to typhoid fever caused by infection with Salmonella enterica serovar Typhi. Mathur et al. now report that mice lacking Toll-like receptor 11, which is absent in humans, can be lethally infected with S. Typhi, a breakthrough that promises to speed the development of better vaccines.

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Figures

Figure 1
Figure 1. TLR11-Mediated Innate Immunity to Salmonella Typhi in the Mouse Intestine
TLR11 is expressed by small intestinal epithelial cells and by mononuclear phagocytes in the lamina propria. Mathur et al. (2012) report that TLR11 recognition of the Salmonella Typhi flagellin protein enhances epithelial resistance to bacterial invasion and promotes cytokine production by mononuclear cells to enhance systemic resistance to bacterial dissemination. This may help to account for the specificity of S. Typhi for humans, who lack TLR11 expression.
See this image and copyright information in PMC

Comment on

  • A mouse model of Salmonella typhi infection.
    Mathur R, Oh H, Zhang D, Park SG, Seo J, Koblansky A, Hayden MS, Ghosh S. Mathur R, et al. Cell. 2012 Oct 26;151(3):590-602. doi: 10.1016/j.cell.2012.08.042. Cell. 2012. PMID: 23101627 Free PMC article.

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