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Review
. 2012 Nov;32(4):587-600.
doi: 10.1016/j.iac.2012.08.001. Epub 2012 Sep 28.

Update on diffuse alveolar hemorrhage and pulmonary vasculitis

Megan L Krause  1 , Rodrigo Cartin-Ceba, Ulrich Specks, Tobias Peikert
Affiliations
Review

Update on diffuse alveolar hemorrhage and pulmonary vasculitis

Megan L Krause et al. Immunol Allergy Clin North Am. 2012 Nov.

Abstract

Diffuse alveolar hemorrhage is a clinical syndrome that can be a manifestation of multiple different causes. Identification of the underlying etiology is of utmost importance and dictates treatment. Pulmonary vasculitis including antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a common cause of diffuse alveolar hemorrhage. For AAV, treatment includes induction followed by maintenance therapy. Rituximab has an increasing role in the treatment of AAV.

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Figures

Figure 1
Figure 1
Pathologic Findings of Diffuse Alveolar Hemorrhage. A. Organizing diffuse alveolar hemorrhage with hemosiderin laden macrophages with surrounding fibrosis, B. Pulmonary capillaritis, arrow head leukocytoclastic inflammation. (The Images are courtesy of Dr. Marie Christine Aubry, MD, Mayo Clinic, Rochester, MN)
Figure 2
Figure 2
Radiographic Findings of Diffuse Alveolar Hemorrhage. A. Chest x-ray with bilateral patchy infiltrate. B. CT images with bilateral ground glass infiltrates with associated necrotizing nodule in right upper lobe.
See this image and copyright information in PMC

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