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Comment
. 2012 Nov;44(11):1173-4.
doi: 10.1038/ng.2451.

Tracking the evolution of cancer methylomes

Arnaud R Krebs  1 , Dirk Schübeler
Affiliations
Comment

Tracking the evolution of cancer methylomes

Arnaud R Krebs et al. Nat Genet. 2012 Nov.

Abstract

Cellular transformation in cancer has long been associated with aberrant DNA methylation, most notably, hypermethylation of promoter sequences. A new study uses a clever approach of selective high-resolution profiling to follow DNA methylation over a time course of cellular transformation and challenges the notion that hypermethylation in cancer arises in an orchestrated fashion.

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References

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