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Comment
. 2012 Nov;44(11):1174-6.
doi: 10.1038/ng.2448.

Older males beget more mutations

Matthew Hurles  1
Affiliations
Comment

Older males beget more mutations

Matthew Hurles. Nat Genet. 2012 Nov.

Abstract

Three papers characterizing human germline mutation rates bolster evidence for a relatively low rate of base substitution in modern humans and highlight a central role for paternal age in determining rates of mutation. These studies represent the advent of a transformation in our understanding of mutation rates and processes, which may ultimately have public health implications.

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References

    1. Nature. 2012 Apr 04;485(7397):246-50 - PubMed
    1. PLoS Genet. 2010 Oct 14;6(10):e1001154 - PubMed
    1. Nat Genet. 2011 Jun 12;43(7):712-4 - PubMed
    1. Ann Eugen. 1947 Jun;13(4):262-71 - PubMed
    1. Genetics. 2000 Sep;156(1):297-304 - PubMed

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