Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Aug;15(Suppl 1):1-10.
doi: 10.1007/BF02867539.

Genes of renin angiotensin system and coronary heart disease

T F Ashavaid  1 , K K Shalia, K G Nair, J J Dalal
Affiliations

Genes of renin angiotensin system and coronary heart disease

T F Ashavaid et al. Indian J Clin Biochem. 2000 Aug.

Abstract

Coronary constriction, proliferation of smooth muscle cells and arrhythmia are involved in the pathophysiology of coronary heart disease and its complications such as myocardial infarction and sudden death. All these effects are favoured by high angiotensin II levels. Angiotensin II is the main effector molecule of the renin angiotensin system and it acts through angiotensin II type receptors. Genetically determined differences in the expression of the components of this system could adversely affect angiotensin II concentration and subsequently heart. Consequently each component of this system represents a potential candidate in the etiology of cardiovascular disease. In this article we review the variation of the angiotensin I converting enzyme, angiotensin II type I receptor and angiotensinogen genes and their association with cardiovascular disease.

Keywords: Coronary heart disease; Gene polymorphism; Renin angiotensin system.

PubMed Disclaimer

References

    1. Davies M.J. The Pathophysiology Of Coronary Atherosclerosis. In: Schlant RC., Wyand AR., O'Rourke RA., Roberts R., Sonnenblick EH, editors. Hurst's The Heart; Arteries and Veins. 8th edition. New York: McGraw-Hill Publication; 1994. pp. 1009–1010.
    1. Kannel W.B. Bishop lecture. Contribution of the Framingham study to preventive Cardiology. J. Am. Coll. Cardiol. 1990;15:206–211. doi: 10.1016/0735-1097(90)90203-2. - DOI - PubMed
    1. Ashavaid, T.F., Altaf, A.K. and Nair, K.G. (2000) Identification of two LDLR mutations causing FH in Indian subjects by simplified rapid PCR-HDX method. Clin. Chem. (In press). - PubMed
    1. Todur, S.P. and Ashavaid, T.F. (2000) Apolipoprotein E gene polymorphism and serum Lp(a) levels: New risk factors for CHD in Indian population. Abst. XXVI Ann. Conf. Assoc. Clin. Biochem. India, Vellore, India, p 114.
    1. Ashavaid T.F., Nair S., Li S., Nair K.G., Dalal J.J. Hyperhomocyteinemia and the prevalence of methylene tetrahydrofolate reductase mutation in patients with CHD. Abst. San Diego Conference, Nucleic Acid Technologies in Disease Detection. Clin Chem. 1997;43(11):2018–2018.

LinkOut - more resources