Apolipoprotein E4 polymorphism as risk factor for coronary heart disease among Indian subjects
- PMID: 23105342
- PMCID: PMC3453726
- DOI: 10.1007/BF02867947
Apolipoprotein E4 polymorphism as risk factor for coronary heart disease among Indian subjects
Abstract
Apolipoprotein E genotypes and lipid and lipoprotein levels were determined in hypercholesterolemic and angiographically vertified CHD subjects and compared against 90 normolipidemic controls. The ε4 allele was significantly prevalent in the hypercholesterolemic and CHD subjects. Significant increase in total cholesterol levels in apo ε4 containing subjects were observed in the hypercholesterolemic and CHD group. The study suggests that the ε4 allele by influencing the lipid levels could act as a risk factor for CHD.
Keywords: Apolipoprotein E genotypes; alleles.
References
-
- Enas AE, Dhawan J., Petkar S. Coronary artery disease in Asian Indians: Lessons learnt and the role of lipoprotein (a) Indian Heart J. 1997;49:25–34. - PubMed
-
- Gupta R, Prakash H, Majumdar S, Sharma S., Gupta VP. Prevalence of coronary heart disease and coronary risk factors in an urban population of Rajasthan. Indian Heart J. 1995;47:331–338. - PubMed
-
- Hamsten A, Walldius G, Szamosi A, Dahlen G, Faire U. Relationship of angiographically defined coronary artery disease to serum lipoproteins and apolipoproteins in young survivors of myocardial infarction. Circulation. 1986;73(6):1097–1110. - PubMed
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