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. 2003 Jul;18(2):80-6.
doi: 10.1007/BF02867371.

Maternal and fetal indicators of oxidative stress in various obstetric complications

Guruprasad Rao  1 , Ullas Kamath, Chaerkadi Raghothama, K Sujatha Pradeep, Pragna Rao
Affiliations

Maternal and fetal indicators of oxidative stress in various obstetric complications

Guruprasad Rao et al. Indian J Clin Biochem. 2003 Jul.

Abstract

The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born after premature rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05) as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high (p<0.01). In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation and proteolytic activity in maternal erythrocytes was significantly higher than in controls (p<0.001 and p<0.05 respectively). In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001 and p<0.05 respectively).

Keywords: Lower segment cesarian section; malondialdehyde; premature rupture of membranes; prolonged second stage of labour; proteolytic activity.

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References

    1. Frank L., Sosenko I. Failure of premature rabbits to increase antioxidant enzymes during hyperoxic exposure. Increased susceptibility to pulmonary oxygen toxicity compared with term rabbits. Pediatr. Res. 1991;29:292–296. - PubMed
    1. Frank L., Sosenko I. Development of lung antioxidant enzyme system in late gestation: Possible implications for the prematurely born infant. J. Pediatr. 1987;110:9–14. doi: 10.1016/S0022-3476(87)80279-2. - DOI - PubMed
    1. Wang W., Pang C., Rogers M., Chang A. Lipid peroxidation in cord blood at birth. Am. J. Obstet. Gynecol. 1996;174:62–65. doi: 10.1016/S0002-9378(96)70374-5. - DOI - PubMed
    1. Pitkanen O., Haliman M., Andersson S. Correlation of free oxygen radical induced lipid peroxidation with outcome in very low birth weight infants. J. Pediatr. 1990;116:760–764. doi: 10.1016/S0022-3476(05)82668-X. - DOI - PubMed
    1. Halliwell B., Gutteridge J.M.C. Free radicals in biology and medicine. 2nd ed. Oxford: Clarendon Press; 1989.

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