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. 2005 Jan;20(1):1-8.
doi: 10.1007/BF02893033.

Effect of antimalarials treatment on rat liver lysosomal function-Anin vivo study

Samir P Patel  1 , Subhash D Katewa, Surendra S Katyare
Affiliations

Effect of antimalarials treatment on rat liver lysosomal function-Anin vivo study

Samir P Patel et al. Indian J Clin Biochem. 2005 Jan.

Abstract

Effects of treatmentin vivo with the antimalarials:chloroquine (CQ), primaquine (PQ) and quinine(Q) on lysosomal enzymes and lysosomal membrane integrity were examined. Treatment with the three antimalarials showed an apparent increase in the membrane stability. CQ treatment resulted in increase in both the 'free' and 'total' activities of all the enzymes i.e. acid phosphatase, RNase II, DNase II and cathepsin D. PQ treatment lowered the 'free' and 'total' activities of acid phosphatase and cathepsin D, but the DNase II activities increased. Treatment with Q resulted in increased 'free' and 'total' activities of RNase II and DNase II. While 'free' activities of acid phosphatase and cathepsin D were low; the 'total' activities increased significantly. Our results suggest that a generalized increase in free nucleases activities following prolonged treatment with antimalarials may lead to cell damage and/or necrosis.

Keywords: DNase II; RNase II; T/F ratio; acid phosphatase; cathepsin D; lysosomal enzymes; lysosomes.

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References

    1. Leslie T.W. Drugs used in the chemotherapy of protozoal infections- Malaria. In: Gilmann A.G., Rall T.W., Nies A.S., Taylor P, editors. The pharmacological basis of therapeutics. 8th ed. New York: Pergamon press; 1990. pp. 959–997.
    1. Foley M., Tilley L. Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents. Pharmacol. Ther. 1998;79(1):55–87. doi: 10.1016/S0163-7258(98)00012-6. - DOI - PubMed
    1. Deepalakshmi P.D., Parasakthy K., Shanti S. Devrajan NS, Effect of chloroquine on rat liver mitochondria. Ind. J. Exp. Biol. 1994;32:797–801. - PubMed
    1. Essien E.E., Ette E.I. Effects of chloroquine and didesethylchloroquine on rabbit myocardium and mitochondria. J. Pharm. Pharmacol. 1986;38(7):543–546. - PubMed
    1. Jarzyna R., Lenarcik E., Bryla J. Chloroquine is a potent inhibitor of glutamate dehydrogenase in liver and kidney-cortex of rabbit. Pharmacol. Res. 1997;35(1):79–84. doi: 10.1006/phrs.1996.0108. - DOI - PubMed

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