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. 2008 Jul;23(3):279-82.
doi: 10.1007/s12291-008-0062-y. Epub 2008 Oct 1.

Diagnostic strategies for subclinical hypothyroidism

Shruti Mohanty  1 , W Amruthlal, G C Reddy, G Kusumanjali, A S Kanagasabapathy, Pragna Rao
Affiliations

Diagnostic strategies for subclinical hypothyroidism

Shruti Mohanty et al. Indian J Clin Biochem. 2008 Jul.

Abstract

The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri - iodothyronine (T(3)), thyroxine (T(4)), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74% of study subjects had elevated anti-TPO levels.61% patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.

Keywords: Anti TPO; Hypothyroidism; T3; T4; TSH; Thyroid Profile.

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