Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Oct 26;12(3):464-74.
doi: 10.1102/1470-7330.2012.0042.

Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma

Hsin-Yi Wang  1 , Hueisch-Jy Ding, Jin-Hua Chen, Chih-Hao Chao, Yu-Yu Lu, Wan-Yu Lin, Chia-Hung Kao
Affiliations
Review

Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma

Hsin-Yi Wang et al. Cancer Imaging. .

Abstract

Objectives: Positron emission tomography (PET) using fluorodeoxyglucose (FDG) is useful for restaging renal cell carcinoma (RCC) and detecting metastatic diseases but is less satisfactory for detecting primary disease. We evaluated whether the integration of computed tomography (CT) scans with the PET system could increase the applicability of FDG-PET for RCC.

Methods: The MEDLINE databases were searched for relevant studies published since 2001. Two reviewers independently assessed the methodological quality of each study identified. We then performed a meta-analysis of the sensitivity and specificity of FDG-PET findings as reported in all the selected studies.

Results: Fourteen studies were eligible for inclusion. The pooled sensitivity and specificity of FDG-PET were 62% and 88% respectively, for renal lesions. For detecting extra-renal lesions, the pooled sensitivity and specificity of FDG-PET were 79% and 90%, respectively, based on the scans, and 84% and 91% based on the lesions. The use of a hybrid FDG-PET/CT to detect extra-renal lesions increased the pooled sensitivity and specificity to 91% and 88%, respectively, with good consistency.

Conclusions: For RCC, combining the FDG-PET and CT systems is helpful for detecting extra-renal metastasis rather than renal lesions. The hybrid PET/CT system has comparable sensitivity and specificity with PET in detecting extra-renal lesions of RCC.

Advances in knowledge: The FDG-PET and PET/CT systems are both useful for detecting extra-renal metastasis in renal cell carcinoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Summary of the sensitivity and specificity as well as the sROC curve for detecting renal lesions of RCC by FDG-PET.
Figure 2
Figure 2
Summary of the sensitivity and specificity as well as the sROC curve for detecting extra-renal lesions of RCC on a scan basis by FDG-PET.
Figure 3
Figure 3
Summary of the sensitivity and specificity as well as the sROC curve for detecting extra-renal lesions of RCC on a lesion basis by FDG-PET.
Figure 4
Figure 4
Summary of the sensitivity and specificity for detecting extra-renal lesions of RCC on a scan basis by FDG-PET/CT.
See this image and copyright information in PMC

References

    1. Frank IN, Graham SD, Nabors WL. Urologic and male genital cancers. In: Holleb AI, Fink DJ, Murphy GP, editors. Clinical oncology. Atlanta, GA: American Cancer Society; 1991. pp. 283–287.
    1. Hustinx R, Benard F, Alavi A. Whole-body FDG-PET imaging in the management of patients with cancer. Semin Nucl Med. 2002;32:35–46. PMid:11839068. - PubMed
    1. Scott AM. Current status of positron emission tomography in oncology. Australas Radiol. 2002;46:154–162. doi: 10.1046/j.1440-1673.2001.01025.x. . PMid:12060153. - DOI - PubMed
    1. Martinez de Llano SR, Delgado-Bolton RC, Jimenez-Vicioso A, et al. [Meta-analysis of the diagnostic performance of 18F-FDG PET in renal cell carcinoma] Rev Esp Med Nucl. 2007;26:19–29 (in Spanish). doi: 10.1157/13097378. . PMid:17286945. - DOI - PubMed
    1. Tavani A, La Vecchia C. Epidemiology of renal-cell carcinoma. J Nephrol. 1997;10:93–106. PMid:9238616. - PubMed

MeSH terms

Substances