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. 2012 Oct;78(5):116-20.
doi: 10.5935/1808-8694.20120018.

Non syndromic cleft lip and palate: relationship between sex and clinical extension

[Article in English, Portuguese]
Daniella Reis Barbosa Martelli  1 , Renato Assis Machado, Mário Sérgio Oliveira Swerts, Laíse Angélica Mendes Rodrigues, Sibele Nascimento de Aquino, Hercílio Martelli Júnior
Affiliations

Non syndromic cleft lip and palate: relationship between sex and clinical extension

[Article in English, Portuguese]
Daniella Reis Barbosa Martelli et al. Braz J Otorhinolaryngol. 2012 Oct.

Abstract

Cleft lip and/or palate represent the most common congenital anomaly of the face.

Aim: To describe the correlation between non-syndromic cleft lip and/or palate and gender, and its severity in the Brazilian population.

Methods: Cross-sectional study, between 2009 and 2011, in a sample of 366 patients. The data was analyzed with descriptive statistics and multinomial logistic regression with a 95% interval to estimate the likelihood of the types of cleft lip and/or palate affecting the genders.

Results: Among the 366 cases of non-syndromic cleft lip and/or palate, the more frequent clefts were cleft lip and palate, followed respectively by cleft lip and cleft palate. The cleft palates were more frequent in females, while the cleft lip and palate and cleft lips only predominated in males. The risk of cleft li in relation the cleft palate was 2.19 times in males when compared to females; while the risk of cleft lip and palate in relation to cleft palate alone was 2.78 times in males compared to females.

Conclusion: This study showed that there were differences in the distribution of the non-syndromic cleft lip and/or palate between males and females.

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References

    1. Carinci F, Scapoli L, Palmieri A, Zollino I, Pezzetti F. Human genetic factors in non syndromic cleft lip and palate: an update. Int J Pediatr Otorhinolaryngol. 2007;71(10):1509–1519. - PubMed
    1. Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, et al. Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from Scandinavia. PLoS ONE. 2009;4(4):e5385. - PMC - PubMed
    1. de Castro Monteiro Loffredo L, Freitas JA, Grigolli AA. Prevalence of oral clefts from 1975 to 1994, Brazil. Rev Saúde Pública. 2001;35(6):571–575. - PubMed
    1. Martelli-Junior H, Porto LV, Martelli DR, Bonan PR, Freitas AB, Della Coletta R. Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000-2005. Braz Oral Res. 2007;21(4):314–317. - PubMed
    1. Nunes LMN, Queluz DP, Pereira AC. Prevalência de fissuras labiopalatais no município de Campos dos Goytacazes-RJ, 1999-2004. Rev Bras Epidemiol. 2007;10(1):109–116.

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