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Case Reports
. 2012 Oct 30:13:141.
doi: 10.1186/1471-2369-13-141.

Acute kidney injury after ingestion of rhubarb: secondary oxalate nephropathy in a patient with type 1 diabetes

Marc Albersmeyer  1 , Robert Hilge, Angelika Schröttle, Max Weiss, Thomas Sitter, Volker Vielhauer
Affiliations
Case Reports

Acute kidney injury after ingestion of rhubarb: secondary oxalate nephropathy in a patient with type 1 diabetes

Marc Albersmeyer et al. BMC Nephrol. .

Abstract

Background: Oxalosis is a metabolic disorder characterized by deposition of oxalate crystals in various organs including the kidney. Whereas primary forms result from genetic defects in oxalate metabolism, secondary forms of oxalosis can result from excessive intestinal oxalate absorption or increased endogenous production, e.g. after intoxication with ethylene glycol.

Case presentation: Here, we describe a case of acute crystal-induced renal failure associated with excessive ingestion of rhubarb in a type 1 diabetic with previously normal excretory renal function. Renal biopsy revealed mild mesangial sclerosis, but prominent tubular deposition of oxalate crystals in the kidney. Oxalate serum levels were increased.

Conclusion: Acute secondary oxalate nephropathy due to excessive dietary intake of oxalate may lead to acute renal failure in patients with preexisting renal disease like mild diabetic nephropathy. Attention should be payed to special food behaviors when reasons for acute renal failure are explored.

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Figures

Figure 1
Figure 1
(A) Oxalate crystals (arrows) within the renal tubular lumen in a hematoxylin eosin-stained section (original magnification x200) and (B) under polarisation light microscopy (original magnification x100). Adjacent glomeruli show mild diabetic mesangial sclerosis.
See this image and copyright information in PMC

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